No abstract

In patients with the metabolic syndrome, doxazosin treatment not only decreases platelet activity, as measured by a change in MPV, but also improves metabolic abnormalities. Amlodipine also has beneficial effects in patients with the metabolic syndrome but has no effect on MPV.

Plant stanols have been recommended in combination with individualized dietary interventions to reduce plasma cholesterol concentrations. Even though yogurt is consumed in high quantities in

Multiple myeloma is a hematological malignancy characterized by a clonal proliferation of plasma cells in the bone marrow. Extramedullary dissemination of multiple myeloma is uncommon. Only in rare cases, the malignant plasma cells of multiple myeloma had infiltrated the lung parenchyma. In this case report, we presented a case of multiple myeloma with lung plasmacytoma, in a 42-year-old patient, hospitalized for pain and infiltrative mass in the right lung. The results of his initial evaluation with computed tomography and positron emission tomograpy scanning, resembled lung tumor with bone metastasis. Surprisingly, biopsies from lung tumor and bone metastasis, revealed malignant plasma cells. We found M spike in protein electrophoresis and lambda monoclonal band in immune electrophoresis. A bone marrow biopsy evaluation was done and justified multiple myeloma diagnosis before hematology referral. Multiple myeloma diagnosis at the age of 42 is quite rare.Keywords: Cancer; lung; metastasis; myeloma.Multipl miyelom kemik iliğinde plasma hücrelerinin klonal proliferasyonu ile karekterize hematolojik malign bir hastalıktır. Multipl miyelomda ekstramedüller yayılım sık değildir. Çok nadir olgularda multipl miyelom nedenli plazma hücrele-ri akciğer parankimini infiltre eder. Bu yazıda, sağ akciğerde infiltratif kitle ve ağrı nedeniyle hastaneye yatırılan, akciğer plasmasitomlu multipl miyelomu olan 42 yaşında bir hasta sunuldu. Bilgisayarlı tomografi ve pozitron emisyon tomografisi ile yapılan ilk değerlendirmede kemik metastası olan akciğer tümörüne benzetildi. Akciğerdeki tümörden ve kemikteki metastastan yapılan biyopside sürpriz olarak malign plazma hücreleri görüldü. Protein elektroforezinde M spike ve immün elektroforezde monoklonal lamda bandı bulundu. Kemik iliği biyopsisi yapıldı ve multipl miyelom tanısı konarak hematolojiye refere edildi. Multipl miyelom 42 yaşında nadir görülür.

Empiric antibiotic therapy is still habitually prescribed to patients with acute exudative tonsillitis in many out-patient clinics in Turkey, despite many studies worldwide showed low group A beta hemolytic streptococci (GABHS) and high viral infection incidence in those patients. In this study, we tried to show the real frequency of GABHS in acute exudative tonsillitis in Istanbul over a 14-year period. Methods:In this retrospective study, we looked through the patient files with acute exudative tonsillitis who had admitted internal medicine and ear-nose-throat out-patient clinics of our hospital in Istanbul, Turkey between 2000 and 2014. We included all patients with the diagnosis of exudative tonsillitis who had a throat swap and culture. We obtained data from the results of throat swab cultures for GABHS. Demographic data and microbiological results were analyzed. Results: Results of throat swab cultures of 967 patients were enrolled in this study (525 male, 442 female; mean age 21±7 years; range 14 to 70 years). In our retrospective analysis GABHS was isolated in only 105 (10.8%) of all patients. Of those patients in whom GABHS were isolated, 56 (5.7%) were males and 49 (5.06%) females. There was no significant difference between men and women with respect to infection rate (p>0.05). Conclusion:The incidence of GABHS was also low in acute exudative tonsillitis in Istanbul over a 14-year period. Acute exudative tonsillitis was caused by GABHS in only about 10% of all our patients. Tests such as throat culture and rapid antigen test must be performed as soon as possible to confirm diagnosis when there is a suspicion of GABHS infection but routine or immediate antibiotic therapy for acute exudative tonsillitis in adults is not necessary.