Introduction:Patients with psoriasis may develop several comorbidities. Objective: To determine the clinical characteristics and comorbidities associated with psoriasis. Material and methods: This retrospective case-control study involved 422 adult patients with psoriasis and 444 healthy individuals. The inclusion criteria for patients were: over 18 years old and at least one-year history of confirmed psoriasis. Data, such as age, gender, body mass index, smoking, and alcohol consumption habits were analyzed in addition to detailed physical and dermatological examination. Results: The common comorbidities in patients with psoriasis were depression (n = 144, 34%), hypertension (n = 168, 39.81%), diabetes mellitus (n = 100, 23.7%), coronary artery disease (n = 59, 13.9%) and metabolic syndrome (n = 67, 15.88%). The most common conditions in the control group were hypertension (n = 62, 13.96%), hyperlipidemia (n = 62, 13.96%), diabetes mellitus (n = 42; 9.46%), metabolic syndrome (n = 32; 7.21%) and coronary artery disease (5.41%). Patients with psoriasis are at a higher risk for obesity compared to healthy controls (OR = 1.99; p < 0.0001). In addition, smoking and alcohol consumption were significantly higher in patients with psoriasis (p < 0.0001). Conclusions: These results indicate an increased prevalence of obesity, hyperlipidemia, hypertension, cardiovascular diseases, diabetes, metabolic syndrome, and depression in patients with psoriasis.

Introduction: Allergic sensitization to aeroallergen (atmospheric pollen and fungal spores) is the most common seasonal allergy trigger. The main reason for that study is unexpected skin prick test results obtained in our dermatology department. For that reason, we would like to check whether the consequences depend on cross-reactivity or aeroallergen invasion. Aim: The purpose of the present study is to determine the pollen types, including the amount and concentration of the native and invasive pollen in the Çanakkale Region during the spring and summer periods. The main reason for that study is unexpected skin prick test results obtained in our dermatology department. For that reason, we would like to check whether the consequences depend on cross-reactivity or aeroallergen invasion. Material and methods: The pollen monitoring station was placed in the Çanakkale Central Public Park. The sampling was performed by a Durham trap based on the gravimetric method. The slide was replaced with a new one every week and evaluated by 10× ocular and 40× apochromatic lenses. Results: The primary pollen producers were the following arboreal plants: Pinus sp. (65.0%), Quercus sp. (9.37%), Platanus sp. (4.29%), Moraceae (3.87%), Oleaceae (2.71%). The pollen distribution of herbaceous plants and bushes were determined as Poaceae (4.34%), Chenopodiaceae (1.99%), Plantago sp. (1.97%) and Xanthium sp. (1.35%). In addition to our current knowledge, Ambrosia pollens' first record was found with a ratio of 0.22% in the Çanakkale atmosphere. These invasive plants have most probably entered the atmosphere with long-distance transport. Conclusions: Aerobiological monitoring is essential to determine allergen variety and concentrations to find a cure against pollinosis. The health professionals should apply a skin prick test against a significant allergen, i.e. Ambrosia pollens even if there is no previous report in the region. The authors also advised clinicians to be aware of pollen invasion to ensure that patients do not have false-negative results.

Introduction:The house dust mite is a major cause of allergic disease. The standard diagnostic techniques consist of determination of the immunoglobulin E (IgE) level in blood and the application of a skin prick test. The skin prick test results are not always reliable because only 2 common species are determined by the test. Thus, the prevalence of mite allergy in a population requires microscopic analysis of collected samples. Aim: This cross-sectional study was conducted to investigate whether skin prick test results are compatible or not with the presence of mites in a house. Material and methods: A total of 84 allergic patients were included in the study. A questionnaire was applied to detect allergic risk factors. The skin prick test was performed to ascertain if the allergy occurs due to Dermatophagoides pteronyssinus and D. farinae. Patients were requested to take dust samples from their homes to determine the sensitivity of the prick test. Results: In our study, we have shown that D. pteronyssinus and D. Farinae are the common (32.5%), but not the only species, in dust samples. The frequency of mites was found to be 21.4% in dust samples taken from the homes of these patients, and 17.5% of the house dust mite allergen could not be identified without microscopic examination. In this study, we have clearly shown that humidity and feeding animals increase the dust mite development risk by 1.74 and 1.82 times, respectively. Conclusions: Dermatologists should request dust samples from patients with allergic problems for detailed examination such as microscopy or ELISA.

Obesity is a disease that is affected by environmental conditions as well as genetic predisposition. This is a case-control study that aimed to investigate the relationship between FTO rs9939609 polymorphism and obesity. The relation between the rs9939609 polymorphism and obesity in 80 ower-weight (BMI≥30) and 131 under/normal weight (BMI<30) subjects was examined. The allele and genotype frequencies of each group were determined by the allele counting method. The relationship between single nucleotide exchange and obesity risk was calculated using the odds ratio. Statistical analyzes were performed with SPSS 18.0. Results: The frequency of T allele was 0.58 and 0.45 respectively in the healthy and overweight group when allele frequencies of both groups were compared. The change in allele frequency increased the obesity rate by 1.8 fold. The rs99399609 polymorphism increases obesity risk by2.7 fold in the homozygotes model. Conclusions: In this research, we found statistically significant results in allele frequency difference and allele positivity. The relationship between rs9939609 polymorphism and obesity will be highlighted by larger population studies.