Background: Diabetes is the fifth leading cause of death in the world, which reduces the patients' quality of life (QOL) and is considered as an important subject especially in medicine and medical community. The present study aimed at investigating the QOL of diabetic patients in Iran through meta-analysis. Methods: The search was conducted using relevant keywords in national and international databases including Iranmedex, SID, Magiran, IranDoc, Medlib, Science Direct, PubMed, Scopus, Cochrane, Embase, Web of Science. Questionnaires WHOQOL, SF-36, SF-20, DQOL, QOL, PedsQL, ADDQOL, D-39, DQOL-BCI, SWED-QUAL, IRDQOL, PHG-2, EQ-5D, and IDQOL-BCI were used to assess the QOL. Heterogeneity of studies was assessed using I 2 index. Data were analyzed using STATA version 11. Results: In 96 studies of 17,994 people, the mean score of QOL in diabetic patients was based on the questionnaires WHOQOL [66.55 (95% CI: 45.83, 87.26)], D-39 [129.43 (95%CI: 88.77, 170.10)], SF-36 [65.64 (95% CI: 59.82, 71.46)], SF-20 [46.50 (95% CI: 37.19, 55.81], DQOL [61.19 (95% CI: 35.73, 86.66)], QOL [117.91 (95% CI: -62.97, 298.79)], PedsQL [34.36 (95% CI: -31.49, 100.22)], ADDQOL [41.76 (95% CI: 12.01-71.50)], SWED-QUAL [59.19 (95% CI: 21.15, 97.23)], IRDQOL [105.92 (95% CI: 102.73, 109.10)], PHG-2 [61.00 (95%CI: 59.63, 62.37)], EQ-5D [0.62 (95% CI: 0.61, 0.64)], DQOL-BCI [3.40 (95% CI: 3.31, 3.49)], and IDQOL-BCI [22.63 (95% CI: -2.38, 47.64)]. Conclusions: The QOL of diabetic patients was evaluated according to different types of questionnaires and the QOL of diabetic patients was found to be lower than normal population.

Introduction: Stomach cancer is among five common malignancies whose prevalence and incidence are considerably associated with our dietary regime. Thus, the present study aims to conduct a systematic review and meta-analysis to evaluate the relationship between coffee drinking and the risk of stomach cancer. Materials and Methods: A comprehensive literature search of the databases, including Barakat Knowledge Network System, Cochrane, IranDoc, Web of Science, PubMed, SID, Magiran, Scopus, and Google Scholar web browser was conducted using standard keywords. Data analysis of this meta-analysis was conducted using STATA 14 software and P<0.05 was considered as a significant level for tests. Results: A total of 24 studies with a sample size of 990605 were reviewed which showed drinking coffee prevents stomach cancer [OR=0.89, (95% CI: 0.82, 0.98]. However, subgroup analysis by gender found no significant statistical relationship between coffee consumption and stomach cancer risk regarding male or female gender. However, the statistically significant relationship between coffee drinking and stomach cancer risk was assessed in several countries, including Korea, Turkey, Uruguay, Venezuela, and Singapore, with the largest effect being reported in Turkey [OR=0.51 (95% CI: 0.39,0.67]. Conclusion: Coffee consumption prevents and reduces the risk of developing stomach cancer.

Neonatal hypoglycemia is one of the major complications in neonatal wards, requiring rapid diagnosis and treatment to prevent its complications. Dextrose gel is used as a cheap and safe choice. Thus, the present systematic review and meta-analysis study aimed to investigate the effects of oral dextrose gel in preventing and treating neonatal hypoglycemia. To find the relevant articles, the national databases, including Barekat Gostar, SID, Magiran, IranDoc, and international databases, including PubMed, Scopus, Web of Science, Cochrane, and Google Scholar were consulted with standard keywords. The data were analyzed using the STATA 14 software, while the P value < 0.05 was considered significant. In 9 articles with a sample size of 8755 neonates, the mean neonatal weight ranged from 2890 to 3669 g. The share of neonates born through normal vaginal delivery equaled 61%, while 16% had low birth weight (below 2500 g), 16% had high birth weight (above 4500 g), 51% had diabetic mothers, 20% were premature, and 88% were singleton. Oral dextrose gel reduced the risk of neonatal hypoglycemia by OR=0.83 (95% CI: 0.75-0.93). However, neonatal hypoglycemia treatment with oral dextrose gel had an OR=0.78 (95% CI: 0.57-1.07), which was not statistically significant. Oral dextrose gel was effective in preventing neonatal hypoglycemia.

Background: Neonatal hypoglycemia is the most common metabolic abnormality affecting newborns and contributes to increased morbidity and mortality. Objectives: The present systematic review and meta-analysis aim to explore the prevalence and risk factors associated with neonatal hypoglycemia in Iran. Methods: A systematic search was performed in Iranian and international databases, including SID, MagIran, Barakat Knowledge Network System, PubMed, Scopus, Web of Science, and the Google Scholar search engine searched for relevant articles using valid keywords. The search process was updated until September 28, 2021. Data were analyzed using STATA 14 software, and the significance level for all tests was considered P<0.05. Results: In 14 reviewed articles with a sample size of 18217, the prevalence of hypoglycemia in Iranian newborns was 29% [95%CI: 21%, 37%, P=0.0001] (64% in boys and 37% in girls). The hypoglycemia prevalence was 67% in infants born via cesarean section compared to 24% in vaginally delivered infants. The lowest and highest prevalence of neonatal hypoglycemia was observed in Mashhad (12%) and Arak (53%), respectively. The most common risk factors for neonatal hypoglycemia in Iran were infant prematurity (61%), septicemia (45%), respiratory distress syndrome (RDS) (26%), small for gestational age (SGA) (26%), maternal diabetes (21%), hypocalcemia (19%), intrauterine growth restriction (IUGR) (9%) and perinatal asphyxia (8%). Conclusions: Neonatal hypoglycemia is very common in Iran, affecting nearly one-third of Iranian newborns. The prevalence of hypoglycemia in boys was almost twice as high as that in girls and 2.5 times higher in infants born by cesarean section than in infants delivered vaginally. Furthermore, prematurity was reportedly the most common risk factor for neonatal hypoglycemia in Iran.

Introduction: Rheumatoid arthritis is a chronic autoimmune disease with numerous side effects. Since long ago, the impact of fish consumption on treating this disease has been of researchers’ interest. Hence, this study aims to examine the relationship between fish consumption and the risk of rheumatoid arthritis through a systematic review and a meta-analysis method. Materials and Methods: For this meta-analysis to reach the research related to the case study, the following databases: PubMed, Scopus, Web of Science, Cochrane, and the Google Scholar search engine were conducted. The data were analyzed using the STATA 14, and the significance level of the tests was P <0.05. Results: There were 2166980 people (20218 cases and 2146762 controls) in this case study, and the age range of the patients was between 18 and 89. The studies were published between 1991 and 2022 and estimated the odds ratio (OR) of fish consumption and rheumatoid arthritis as (OR =0.83; 95% CI: 0.78, 0.89). This measure was (OR =0.79; 95% CI: 0.72, 0.87) in six case-control studies and (OR =0.86; 95% CI: 0.78, 0.94) in 7 cohort studies. In addition, the effect of fish consumption on reducing the rheumatoid arthritis development was more in people who had consumed fish 2 or less than 2 times a week compared to people who consumed fish more than 2 times every week. Conclusion: Fish consumption reduces the rheumatoid arthritis extension; therefore, these patients are advised to include fish in their diet.