Neurodegenerative
disorders, caused by prone-to-aggregation proteins,
such as Alzheimer disease or Huntington disease, share other traits
such as disrupted homeostasis of essential metal ions, like copper.
In this context, in an attempt to identify Cu
2+
chelating
agents, we study several organic compounds (ethylenediaminetetraacetic
acid, phenylenediamine, metformin, salicylate, and trehalose) and
organic extracts obtained from
Bacopa monnieri
L., which has been used in Ayurvedic therapies and presented a broad
spectrum of biological properties. For this purpose, UV–visible
spectroscopy analysis and electrochemical measurements were performed.
Further, biological assays were performed in
Caenorhabditis
elegans
models of polyQ toxicity, in an attempt to
obtain better insights on neurodegenerative disorders.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.