The fast-developing multimorbidity is often a negative prognostic factor for disability, particularly among older populations, and is associated with intellectual, psychological, and social adverse outcomes. Practices must target patients with complex multimorbidity and adopt the principle of continuity of care through routine extended consultations allowing protected time to manage problems encountered in chronic diseases. This brief communication presents some challenges and solutions for non-communicable disease multimorbidity. Accordingly, research funders must call for multimorbidity-focused investigations to mitigate the impact of multimorbidity on patients.