This article describes a new learning model in biotechnology learning. The proposed model was designed while considering the development of 21st century skills using learning models that can enhance creative thinking and collaboration skills. Using a mixed-method (qualitative and quantitative) approach, the authors aimed at identifying the effect of the Identify, Literature Review, Construct, Create, and Communicate Learning Model implemented on Biology and Natural Science undergraduate students. As an example, we illustrate the proposed data collection technique for the assessment of creative thinking and collaboration skills using a written test and observation data, respectively. Our proposed learning model developed students' creative thinking and collaboration skills in two classes with 113 participants who enrolled in a course in Biotechnology. The new model's effectiveness is confirmed by calculating the overall mean scores of creative thinking assessment in the Biology and Natural Science classes, which are 87.42% and 92%, respectively, with an excellent category. Similarly, the results regarding students' collaboration skills in the Biology and Natural Science classes showed the scores of 84.06% and 84.94%, respectively, also with an excellent category. Our findings reveal that students' creative thinking and collaboration skills can be developed by using the Identify, Literature Review, Construct, Create, and Communicate learning model. The model can thus be used for enhancing other 21st century skills, such as critical thinking and communication skills, among others.

The aim of this study is to determine the effect of the Engineering Design Process (EDP) learning model in improving 21st Century skills, students' creative thinking and communication skills on the subject of basic concept of genetics. Using a mixed-methods (qualitative and quantitative) approach, the authors aimed at identifying the effect of the EDP learning model implemented on Science Education undergraduate students, Manado State University. Our proposed learning model developed students’ creative thinking and communication skills in one class with 20 participants who enrolled in a course in General Biology I. Data collection techniques were used to assess creative thinking and communication skills, using written test data and observation data, respectively. The effectiveness of the EDP learning model is confirmed by calculating the average overall score of students' creative thinking assessment of 88,44% with an excellent category. Similarly, the results of student collaboration skills showed a score of 82,19% also with an excellent category. Based on these results, it was revealed that students' creative thinking and communication skills could be increased by using the EDP learning model.