COVID-19 infection has shown cardiovascular involvement, particularly when it has a moderate to severe presentation. This alteration has been manifested in arrhythmias, myocarditis, and acute myocardial infarction, among others; persistence of these cardiovascular alterations in the short and medium term has been documented. In Latin America there are no reports of long-term cardiovascular sequelae. We present the case of a 46-year-old female with no previous history of cardiovascular disease who developed a severe COVID-19 infection, positive by PCR, requiring prolonged orotracheal intubation. Treatment was based on steroids, antibiotic therapy, and anticoagulants. Transthoracic echocardiography (TTE) confirmed pericarditis during the acute phase, with persistent sequelae of cardiac dysfunction. Follow up by the cardiology service was done with echocardiography, manifesting myocardial dysfunction up to 2 years after the acute event. This case shows that severe infection by COVID-19 can cause cardiovascular alterations in addition to producing potentially permanent and disabling sequelae.

A malignant melanoma is an abnormal proliferation of pigmented cells in the body. Half of these tumors have BRAF mutations, with a worse response to treatment. We present the case of a 58-year-old male with a pigmented nodular lesion on the right calf and inguinal lymphadenopathy; a positive biopsy for nodular malignant melanoma (MMN) with the largest diameter of 2 mm, Clark level III and Breslow of 3 mm. Four months after tumor resection of the right pelvic limb and right lymphadenectomy are performed, the patient presents multiple and confluent lesions in the same region. He received treatment with ipilimumab every 6 weeks and nivolumab every 3 weeks, with stability and without progression of the lesions. The patient has one year of survival from the time of diagnosis as well as 10 months of survival from the start of immunotherapy, currently with a year of survival. The combined immunotherapy of ipimumab plus nivolumab has been shown to be one of the most effective regiments for MMN.