Their anthropometrics (weight, height, and blood pressure) were also taken using standardized media. The result showed a statistically significant (P<0.05) increase in the mean value of total Cholesterol, triglyceride and LDL-C, and a statistically significant (P<0.05) decrease in HDL-C in the obese group when compared with control (normal weight) group. There was also statistically significant (P<0.001) increase in atherogenic indices (TC/HDL-C, LDL-C/HDL-C) in the both the overweight and normal weight groups compared with the obese group. There was negative statistically significant (P<0.05) correlation between TC, LDL-C and atherogenic indices in relation to TAC. In the obese group, there were statistically significant positive correlations between TC, TC/HDL-C, LDL-C/HDL-C, LDL-C with MDA. There is significant (P< 0.05) increase in the serum levels of MDA in relation to BMI while TAC showed a significant (P<0.05) decrease in relation to the BMI. The decrease in antioxidant defenses and increases in TC, TG and LDL-C in obese subjects reflects oxidative stress. This could be one of the mechanisms involved in the onset of diseases caused by obesity.