Key Points Question Is treatment at a high-volume center associated with improved survival and neurological outcomes among adult patients with nontraumatic out-of-hospital cardiac arrest (OHCA)? Findings In this systematic review and meta-analysis of 16 articles involving 82 769 patients with OHCA, survival to discharge or 30 days improved with treatment at a high-volume center; there was no association between center volume and good neurological outcomes at 30 days or at hospital discharge. Meaning These findings suggest that treatment at a high-volume center may improve survival but not neurological outcomes in patients with OHCA; more studies evaluating the relative importance of center volume compared with other variables associated with survival outcomes in these patients are required.

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