As scientific publication rates increase, knowledge acquisition and the research development process have become more complex and time-consuming. Literature-Based Discovery (LBD), supporting automated knowledge discovery, helps facilitate this process by eliciting novel knowledge by analysing existing scientific literature. This systematic review provides a comprehensive overview of the LBD workflow by answering nine research questions related to the major components of the LBD workflow (i.e., input, process, output, and evaluation). With regards to theinputcomponent, we discuss the data types and data sources used in the literature. Theprocesscomponent presents filtering techniques, ranking/thresholding techniques, domains, generalisability levels, and resources. Subsequently, theoutputcomponent focuses on the visualisation techniques used in LBD discipline. As for theevaluationcomponent, we outline the evaluation techniques, their generalisability, and the quantitative measures used to validate results. To conclude, we summarise the findings of the review for each component by highlighting the possible future research directions.

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The vast nature of scientific publications brings out the importance of Literature-Based Discovery (LBD) research that is highly beneficial to accelerate knowledge acquisition and the research development process. LBD is a knowledge discovery workflow that automatically detects significant, implicit knowledge associations hidden in fragmented knowledge areas by analysing existing scientific literature. Therefore, the LBD output not only assists in formulating scientifically sensible, novel research hypotheses but also encourages the development of cross-disciplinary research. In this systematic review, we provide an in-depth analysis of the computational techniques used in the LBD process using a novel, up-to-date, and detailed classification. Moreover, we also summarise the key milestones of the discipline through a timeline of topics. To provide a general overview of the discipline, the review outlines LBD validation checks, major LBD tools, application areas, domains, and generalisability of LBD methodologies. We also outline the insights gathered through our statistical analysis that capture the trends in LBD literature. To conclude, we discuss the prevailing research deficiencies in the discipline by highlighting the challenges and opportunities of future LBD research.

Detecting interesting, cross-disciplinary knowledge associations hidden in scientific publications can greatly assist scientists to formulate and validate scientifically sensible novel research hypotheses. This will also introduce new areas of research that can be successfully linked with their research discipline. Currently, this process is mostly performed manually by exploring the scientific publications, requiring a substantial amount of time and effort. Due to the exponential growth of scientific literature, it has become almost impossible for a scientist to keep track of all research advances. As a result, scientists tend to deal with fragments of the literature according to their specialisation. Consequently, important and hidden associations among these fragmented knowledge that can be linked to produce significant scientific discoveries remain unnoticed. This doctoral work aims to develop a novel knowledge discovery approach that suggests most promising research pathways by analysing the existing scientific literature.

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