Mucosa is a protective and lubricating barrier in biological tissue, which has a great clinical inspiration because of its slippery, soft, and hydrophilic surface. However, mimicking mucosal traits on complex surface remains an enormous challenge. Herein, a novel approach to create mucosa‐like conformal hydrogel coating is developed. A thin conformal hydrogel layer mimicking the epithelial layer is obtained by first absorbing micelles, followed by forming covalent interlinks with the polymer substrate via interface‐initiated hydrogel polymerization. The resulting coating exhibits uniform thickness (≈15 µm), mucosa‐matched compliance (Young's modulus = 1.1 ± 0.1 kPa) and lubrication (coefficients of friction = 0.018 ± 0.003), robust interfacial bonding against peeling (peeling strength = 1218.0 ± 187.9 J m–2), as well as high water absorption capacity. It effectively resists adhesion of proteins and bacteria without compromising biocompatibility. As demonstrated by an in vivo cynomolgus monkey model and clinical trial, applications of the mucosa‐like conformal hydrogel coating on the endotracheal tube significantly reduce intubation‐related complications, such as invasive stimuli, mucosal lesions, laryngeal edema, inflammation, and postoperative pain. This work offers a promising prototype for surface decoration of biomedical devices and holds great prospects for clinical translation to enable interventional operations with minimally invasive impacts.

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Hexagon boron nitride (BN) has evolved into a quite competitive building block in electrical and electronic fields. However, exfoliation and functionalization of BN nanosheets (BNNSs) confront a formidable challenge. Herein, an effective and green saccharide-assisted mechanochemical approach was proposed to exfoliate and synchronously functionalize BNNSs. The production yield of BNNSs exhibited a notable enhancement by incorporating saccharides, where the highest yield was up to ∼29.4% with the assistance of glucose. The saccharides enhanced the applied force of ball milling to promote BN delamination. The exfoliated cost is much lower for our proposed approach than for the previously reported exfoliation methods. The theoretical first-principle calculation and experimental results confirmed that the obtained BNNSs (saccharide-g-BNNSs) remained intact and were covalently grafted with saccharides in different degrees. Benefitting from the outstanding comprehensive properties of saccharide-g-BNNSs, their gelatin composite films exhibited multifunctional performance, such as high/anisotropic thermal conductivity, shielding deep blue to the UV light, and flame retardance. Our work paves a promising way to greenly prepare few-layered and functionalized BNNSs and to expedite their applications.

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