Many articles have reported that Rab1A was overexpressed in a variety of human cancers and involved in tumor progression and metastasis. However, the biological function and molecular mechanism of Rab1A in nasopharyngeal carcinoma (NPC) remained unknown until now. Here we found that Rab1A overexpression is a common event and was positively associated with distant metastasis and poor prognosis of NPC patients. Functionally, Rab1A depletion inhibited the migration and EMT phenotype of NPC cells, whereas Rab1A overexpression led to the opposite effect. Furthermore, we reveal an important role for Rab1A protein in the induction of radioresistance via regulating homologous recombination (HR) signaling pathway. Mechanistically, Rab1A activated Wnt/β-catenin signaling by inhibiting the activity of GSK-3β via phosphorylation at Ser9. Then Wnt/β-catenin signaling induced NPC cells radioresistance and metastasis through nuclear translocation of β-catenin and transcription upregulation of HR pathway-related and EMT-related genes expression. In general, this study shows that Rab1A may serve as a potential biomarker for predicting prognosis in NPC patients. Targeting Rab1A and Wnt/β-catenin signaling may hold promise to overcome NPC radioresistance.

The autoimmune thyroid diseases (AITDs) can mainly involve complex interactions between environmental exposure and genetic susceptibility. At present, a majority of AITDs relative genes have been identified, but the results of different ethnic origin are inconsistent. Due to the special genetic characteristics of Uyghur and the unique environment of Xinjiang Uyghur Autonomous Region, the specific pathogenesis of AITDs Uyghur patients remains unknown. Our study was carried out in the group of 100 AITDs Uyghur patients (50 GD and 50 HT) and 50 Uyghur controls. DNA was extracted from peripheral blood leukocytes and region sequencing was performed to identify candidate genes and single nucleotide polymorphisms (SNPs). Following quality control, Chi-square and logistic regression tests were used for detecting the different frequencies of genotypes and alleles between cases and controls. The results of our analyses showed that the polymorphisms of TPO, TG, TSHR and PTPRC genes were associated with AITDs Uyghur patients; CD28, TPO, PTPRC and TG were related to GD; TG, STAT3 and IL2RA were connected with HT. In conclusion, our study may explore several SNPs associate with AITDs in Chinese Uyghur individuals.