Understanding the property evolution of atomically precise nanoparticles atom by atom along the sizecontinuum is critical for selecting potential candidates to assemble nanomaterials with desired functionality,b ut it is very challenging experimentally especially for systems having mixtures of elements such as metal oxides.I nt his work, the capability to oxidize carbon monoxide has been measured experimentally for titania nanocluster anions of (TiO 2 ) n O m À (À3 m 3) across ab road size range in the gas phase.S toichiometric (TiO 2 ) n O À exhibits superior oxidative activity over other clusters of (TiO 2 ) n O m À (m ¼ 6 1) even when the cluster dimensions are scaled up to n = 60, indicating that each atom still influences the chemical behavior of titania nanoparticles composed of % 180 atoms.T he fascinating result not only identifies ap romising building blocko fT i n O 2n+1 for devising new nanoscale titania materials with desirable oxidative activity,but also provides compelling molecular-level evidence for the Mars-van Krevelen mechanism of CO oxidation over titania supports.Nanostructured materials have drawn increasing interest due to their potential applications in various fields such as catalysis, [1] sensors, [2] plasmonics, [3] and biomedicine. [4] The physical and chemical behavior of nanoparticles and nanoclusters is generally size-and composition-dependent. [5] The ability to tailor the nanoparticles at an atomic level is of crucial importance for uncovering promising candidates for the assembly of new materials with specific functionalities.T o date,a tomically precise metallic nanoparticles have been synthesized in solution and in the gas phase, [5,6] allowing for the accurate determination of their structure-property correlations.I nc ontrast, the information about atomically precise metal oxide nanoparticles is rather limited [7] despite the widespread use of metal oxides owing to their catalytic, magnetic, and other properties.Titanium dioxide (TiO 2 )i so ne of the most widely used metal oxide catalysts and catalyst supports for diverse reactions including CO oxidation, [8] water splitting, [9] and pollutants degradation. [10] In the past years,the development of solution procedures has contributed significantly to the synthesis of titania nanoclusters. [11] So far, the largest atomically precise cluster reported is [Ti 52 O 74 ]protected by surface organic ligands. [12] Theh ydrogen evolution activity tests demonstrated that it exhibits higher photocatalytic performance than the small cluster of [Ti 6 O 4 ]. It should be noted that the atomically precise titania nanoclusters synthesized via solution methods were usually scattered over ar ange of discrete sizes and stoichiometric compositions. [11] Moreover, the introduction of various distinct types of ligands to stabilize the specific clusters inevitably influences the related properties. [13] It is very difficult to generalize the correlations of property evolution with cluster size and stoichiometric compositions under comparable condi...

Metallodrugs with fine-tuned coordination between metals and bioactive ligands can achieve cytotoxic effects in cancer therapy and have been considered as a new approach for drug design. However, it has yet to be elucidated whether these metallodrugs target epitranscriptomic proteins for gene expression regulation. This report describes a rhein-based Rh(III)-arene complex, Rh1, that exhibited promising antiproliferative effects in several tumor cell lines. Rh1 induced cell death through the autophagy, cell cycle arrest, and accumulation of intracellular reactive oxygen species (ROS). In addition, Rh1 upregulated the global N 6 -methyladenosine (m 6 A) levels in A549 cells in the fat mass-and obesity-associated protein (FTO)-dependent manner. Collectively, the metal-based FTO inhibitor Rh1 effectively suppressed tumor cell proliferation and modulated the abundance of cellular m 6 A, highlighting the potential of metal-based agents to target and regulate epitranscriptomics for tumor suppression.

Ionothermal reactions of Zn(NO 3 ) 2 with 1,2,4,5benzenetetracarboxylic acid (H 4 BTeC) produced two temperature-controlled zinc(II) coordination polymers, [PMI] 2 [Zn 2 (BTeC)-(H 2 BTeC)] (1) and [PMI] 2 [Zn 3 (BTeC) 2 ]·2H 2 O (2; PMI = 1-methyl-3propylimidazolium). The reaction temperature affects the extent of deprotonation of the H 4 BTeC ligand, leading to different structures and properties. Coordination polymers 1 and 2 show [a]

Yi medicine Shekaqi is the most attractive traditional ethnic medicine due to its significant and diverse pharmacological activities. Two novel flavonoids, including 5,2'-dihydroxy-6-methoxy-7-decyloxyflavone and tenaxin II-7-O-β-D-glucuronopyranosyl acid butyl ester, along with six known flavonoids, were isolated from Yi medicine Shekaqi. Their structures were elucidated based on the analysis of their comprehensive spectral data. The in vitro lipid-lowering activities of the eight compounds showed that all the compounds significantly inhibited the lipopolysaccharide (LPS)-induced increase in the total cholesterol (TC) level, while compounds 1, 4, 6, 7, and 8 significantly inhibited the LPS-induced increase in the triglyceride (TG) level.

Understanding how properties evolve in atomically precise nanoparticles as their size changes atom by atom is critical for designing functional nanomaterials. In their Communication on page 8002 ff., Y.‐X. Zhao, X.‐L. Ding and co‐workers show the superior oxidative activity of stoichiometric (TiO2)nO− over other clusters of (TiO2)nOm− (m≠1) has been experimentally identified even when the cluster dimensions increase to n=60, indicating that each atom still counts in the chemical behavior of titania nanoparticles composed of approximately 180 atoms.