Objective: Adult-onset Still's disease (AOSD) is a rare but clinically well-known polygenic systemic autoinflammatory disease. In this review, we aim to present frontiers in the pathogenesis, clinical features, diagnosis, biomarkers, disease course, prognosis, and treatment in AOSD. Data sources: We retrieved information from the PubMed database up to July 2019, using various search terms and relevant words, including AOSD and Still's disease. Study selection: We included data from peer-reviewed journals. Both basic and clinical studies were selected. Results: Pathogenesis of AOSD involves genetic background, infectious triggers, and immunopathogenesis, mainly the activation of macrophages and neutrophils followed by a cytokine storm. Diagnosis and prognosis evaluation of AOSD is still challenging; therefore, there is an urgent need to identify better biomarkers. Biologic agents, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α antagonists in the treatment of AOSD, have good prospect. Conclusion: This review highlights the advances in pathogenesis, potential biomarkers, disease course, and treatment in AOSD.

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