Immunosuppression due to ischemic stroke is a pivotal factor that can increase the incidence of infectious diseases and mortality after stroke. Electroacupuncture (EA) has been confirmed to improve the prognosis of ischemic stroke model through the parasympathetic nervous system (PNS). The role of EA in regulating immunosuppression after ischemic stroke through PNS is unclear. Using ischemic stroke model, the experiment found that EA exerted the effects in improving survival rate, and neurological deficits, reducing infarct volume, proportion of neuronal apoptosis, and systemic inflammation. Importantly, mice received EA showed a significantly higher in weight, cell number, and α7nAChR levels of spleen, suggesting the improvement of immunosuppression; EA also activated dorsal motor nucleus of the vagus which was the main source of vagus, the main component of the PNS. However, none of these changes were found in mice that did not receive EA. Taken together, EA improves the prognosis of ischemic stroke by activating PNS and regulating spleen immune function in mice.

This study aimed to evaluate the effects of delayed femoral vein ligation on the clinical outcomes of hip disarticulation. We retrospectively reviewed 20 patients with extremity tumors (10 bone tumors and 10 soft tissue sarcomas [STS]) who underwent hip disarticulation. Patients treated for hip disarticulation with synchronous femoral vein ligation (n = 10, regular surgery group) and hip disarticulation with delayed femoral vein ligation (n = 10, delayed ligation group), respectively, were enrolled in this study. The operative time and blood loss were used to evaluate the clinical outcomes. The delayed ligation group had significantly lower operative times than the regular surgery group (P < 0.05). Total, hidden, and intraoperative blood loss were all significantly lower in the delayed ligation group than in the regular surgery group (P < 0.05). However, there were no significant differences in postoperative blood loss. In conclusion, delayed femoral vein ligation could significantly reduce the operative time, hidden blood loss, and intraoperative blood loss in patients undergoing hip disarticulation.