A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM licorice. Our results revealed that all of the calibration curves displayed good linearity. Intra- and inter-day precision for GA ranged from 2.54 to 3.98% and from 4.95 to 7.08%, respectively. The recovery rates for GA were determined to be 96.3–106.4%. All the samples showed satisfactory precision and accuracy in various stability tests. Plasma pharmacokinetic parameters including area under the concentration-time curve (AUC), elimination half-life (t 1/2 ), time to peak concentration(T max ) and peak concentration C max were calculated. No significant difference was found as compared the groups administrating GA with and without other ingredients from TCM.

No abstract

No abstract

The article was submitted to be part of a guest-edited issue. An investigation by the publisher found a number of articles, including this one, with a number of concerns, including but not limited to compromised editorial handling and peer review process, inappropriate or irrelevant references or not being in scope of the journal or guest-edited issue. Based on the investigation's findings the Editor-in-Chief therefore no longer has confidence in the results and conclusions of this article.The author Selim Mahmoud disagrees with the retraction. The authors Menglin Qin, Shaukat Khan, Alibek Issakhov have not responded to correspondence regarding this retraction. The Publisher has not been able to obtain a current email address for author Sajjad Haider. The online version of this article contains the full text of the retracted article as Supplementary Information.

No abstract