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Titanium dioxide is widely utilized as a pigment in the food industry to enhance the whiteness or brightness of foods and beverages. The powdered forms of titanium dioxide used as food ingredients contain a substantial fraction of nanoparticles (d < 100 nm), which may have adverse effects on human health. This is a model study that investigated the molecular interactions between TiO 2 nanoparticles and selected polyphenols, as well as their influence on the in vitro bioavailability and antioxidant activity of the polyphenols. Our results showed that the chemical structure of polyphenols significantly influenced their binding affinity to TiO 2 nanoparticle surfaces, with those possessing vicinal trihydroxy groups having the highest binding affinities. The presence of TiO 2 nanoparticles was shown to reduce the bioavailability of polyphenols using an in vitro digestion model. This effect was mainly ascribed to the formation of large TiO 2 nanoparticle-polyphenol complex agglomerates that could not pass through the pores in the dialysis tube used to simulate the epithelium layer. Additionally, the binding of polyphenols to the surfaces of TiO 2 nanoparticles reduced their antioxidant activity. This study provides valuable insights into the impact of inorganic nanoparticles on the bioavailability and bioactivity of polyphenols.

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