Aerial images have complex backgrounds, small targets, and overlapping targets, resulting in low accuracy of intelligent detection of overhead line insulators. This paper proposes an improved algorithm for insulator breakage detection based on YOLOv5: The ECA-Net (Efficient Channel Attention Network) attention mechanism is integrated into its backbone feature extraction layer, and the effective distinction between background and target is achieved by increasing the weight of important channels. A bidirectional feature pyramid network is added to the feature fusion layer, and large-scale images with more original information are combined to effectively retain small target features. Incorporating a flexible detection frame selection algorithm Soft-NMS (Soft Non-Maximum Suppression) into the prediction layer to re-screen the target frame, thereby reducing the probability of mistaken deletion of overlapping targets. The effectiveness of the improved YOLOv5 algorithm is verified in the actual aerial image dataset, and the results show that the mean Average Precision (mAP) of the improved algorithm is 95.02% and the detection speed FPS (Frames Per Second) can reach 49.4 frames/s, which meets the real-time and accuracy requirements of engineering applications.
Bufadienolide, an essential member of the C-24 steroid family, is characterized by an α-pyrone positioned at C-17. As the predominantly active constituent in traditional Chinese medicine of Chansu, bufadienolide has been prescribed in the treatment of numerous ailments. It is a specifically potent inhibitor of Na+/K+ ATPase with excellent anti-inflammatory activity. However, the severe side effects triggered by unbiased inhibition of the whole-body cells distributed α1-subtype of Na+/K+ ATPase, restrict its future applicability. Thus, researchers have paved the road for the structural alteration of desirable bufadienolide derivatives with minimal adverse effects via biotransformation. In this review, we give priority to the present evidence for structural diversity, MS fragmentation principles, anti-inflammatory efficacy, and structure modification of bufadienolides derived from toads to offer a scientific foundation for future in-depth investigations and views.
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