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(5-11 capsules/day) and vitamin D (400-2400 IU/day). The Schwachman t e s t ranged 55-90. An age matched c o n t r o l group of 7 healthy c h i ldren was a l s o s t u d i e d . BMC, by dual-photon absorptiometry (153 Gd) of t r a b e c u l a r bone i n lumbar v e r t e b r a e was used. Standard deviation s c o r e f o r h e i g h t were l e s s than 1 SO i n both groups. CaAlk p(0.025; m s D V i t 0 n u t r i t i o n a l s t a t u s is i n t h e low normal range and reasonable f o r winter. Using bone width (BW) concept, bone mineral content shows a s i g n i f i c a n t r e i u c t i o n i n CF group, s i m i l a r t o osteoporotic a d u l t s . This can be due t o calcium ntalabsorption. The s i g n i f i c a n t r i s e i n 1,25 0 r e f l e c t s t h e body's calcium needs. Extra c a l c i u n~ and/or v i t D supplements a r e probably required f o r t h o s e p a t i e n t s .MINERAL CONTENT OF THE HUMAN SKULL DURING DEVELOPMENT.N e v i l l e R . Belton and Ian I . Smith, Department of 18 Child L i f e and Health, U n i v e r s i t y of Edinburgh, and Pathology Department, Royal Hospital f o r Sick Children, Edinburgh, Scotland, U . K .Measurements of mineral accumulation i n infancy a r e u s u a l l y r e f e r a b l e t o c a r t i l a g i n o u s bones and y e t the membranous skullbones of preterm i n f a n t s a r e palpably s o f t and c r a n i o t a b e s i s well recognised i n preterm and f u l l t e r m i n f a n t s .Hardening of the v a u l t and i n c r e a s i n g r a d i o l o g i c a l d e n s i t y occur with growth and maturation.Calcium and magnesium c o n t e n t s were measured i n postmortem samples of f r o n t a l bone from 108 c h i l d r e n aged from 20 weeks g e s t a t i o n t o 10 months of l i f e .Samples of bone were d r i e d , ashed and t h e mineral c o n t e n t determined by atomic absorption s p e c t r ophotometry.A small progressive i n c r e a s e i n calcium/100 g t i s s u e was seen i n s t i l l b i r t h s and e a r l y neonatal deaths i n t h e second h a l f of g e s t a t i o n , 21.7g/100 g a t 28 weeks t o 22.6 g/100 g bone a t 40 weeks ( r = 0.23, p <0.02), but t h e r e was l i t t l e subsequent change over t h e f i r s t y e a r of l i f e .The calcium c o n t e n t of many i n f a n t s dying more than 7 days a f t e r b i r t h was reduced.Calcium and magnesium c o n t e n t s were s t r o n g l y c o r r e l a t e d ( r = 0.34, p <0.001) over the whole range of g e s t q t i o n s s t u d i e d .(Magnesium c o n t e n t a t 40 weeks g e s t a t i o n = 0.307 -0.030 (SO), n.19). Our r e s u l t s a r e s i m i l a r t o previous d a t a reported on c a r t i l a g i n o u s long bones (femur and humerus) and suggest t h a t mineral a c c r e t i o n i n c a r t i l a g i n o u s and membranous bones i s s i m i l a r in e a r l y development. -, UK DXD was used t o xeasue BMC i n preterm i n f a n t s ,< 30 weeks g e s t a t i o n a l age (GA) f e d f o d a milk mrrplying w i t h reaimaxled g u i d e l i n e s f o r calcium (Ca) and phosphorus (P...