Human trafficking is a public health predicament, yet current anti-trafficking efforts are limited. Thus, this chapter examines exemplary local efforts across the United States. These highlighted programs provide examples of best-practice, sustainability, multidisciplinary collaboration, and other victim-centered practices. Additionally, a public health theoretical prevention framework is applied in order to provide a deeper understanding of the different stages of trafficking, namely recruitment, identification, and recovery. Applying the preventive framework to the three stages of trafficking creates a deeper comprehension of the issue at hand. Furthermore, this chapter proposes core guiding principles that include evidenced-base approaches to cater to the needs of survivors, the sustainability of programs, and uniformity across the country among anti-trafficking efforts among others. Future recommendations include the development of evidence-based trainings for multiple disciplines that are yet included in the prevention, identification, and recovery of victims of human trafficking.