Introduction and Aims: Cardiovascular (CV) disorders in patients with chronic renal failure undergoing dialysis constitute a major cause of death. Hemodialysis (HD) patients without any apparent CV disorder are also at higher risk of future CV events. In order to provide appropriate intervention and to evaluate new treatments for its prevention, it is important to identify HD patients with an increased CV risk. Methods: We conducted a prospective single center cohort study over 2 year follow up period to investigate whether diastolic function could predict cardiovascular events in 84 HD patients with preserved systolic function. The ratio E/E' was measured by tissue doppler imaging. Patients were divided into two groups whether they experienced or not a CV event. Statistical analyses were performed using the SPSS (version 20) software program. Survival was estimated on the basis of the kaplan Meier curves and compared using the log-rank test. Results: 14 HD patients experienced CV events including acute myocardial infarction, symptomatic angina, heart failure, stroke and peripheral artery disease. The E/E' values (14,46±5,09) in the CV event group were significantly higher than in the non CV event group (7,37±3,02) ( p=0,004). The kaplan Meier analysis shows that the incidence of