The literature insufficiently describes the etiologies of chronic penoscrotal edema, and even more so those of chronic permanent scrotal erythredema. Herein, we report the case of a sixteen-year-old male who presented, in addition to permanent and chronic scrotal erythredema, classical cutaneous manifestations of systemic lupus. The patient had received systemic corticosteroid therapy combined with hydroxychloroquine. The evolution was good, without new outbreaks or recurrences of penoscrotal edema. Apart from the usual urological emergencies, systemic diseases may be involved in scrotal erythredema, which requires long-term medical management.