The analgesic benefit of melatonin and vitamin C as primary or adjuvant agents has been reported in various studies; however, their analgesic effects in the treatment of postoperative pain remain unclear. Thus, we aimed to evaluate the effect of single preoperative dose of oral melatonin or vitamin C administration on postoperative analgesia. In this study, we recruited 165 adult patients undergoing elective major abdominal surgery under general anesthesia. Patients were randomly divided into three equal (n = 55) groups. One hour before surgery, patients received orally melatonin (6 mg) in group M, vitamin C (2 g) in group C, or a placebo tablet in group P. Pain, sedation, patient satisfaction, total morphine consumption from a patient-controlled analgesia device, supplemental analgesic requirement, and the incidence of nausea and vomiting were recorded throughout 24 h after surgery. The mean pain score and total morphine consumption were found significantly lower in both M and C groups compared with group P (p < 0.001). There were no significant differences between group M and C with respect to pain scores (p = 0.117) and total morphine consumption (p = 0.090). Patients requested less supplemental analgesic and experienced less nausea and vomiting in groups M and C compared with group P. In conclusion, preoperative oral administration of 6 mg melatonin or 2 g vitamin C led to a reduction in pain scores, total morphine consumption, supplemental analgesic requirement, and the incidence of nausea and vomiting compared with placebo.

Objective: Lifestyle modification requires extensive information sharing and counseling. However, one-on-one primary care consultations are lacking to cover all necessary components due to time constraints. This preliminary study aims to investigate the feasibility and effects of lifestyle-changing intervention by family physician-led group visits (GVs) on weight management in overweight and obese women. Methods: 60 volunteers fulfilling the inclusion criteria were enrolled. Baseline and 6th month assessments consisted of anthropometric measurements, SF-36 Health Survey, blood variables, exercise test, and resting metabolic rate. Weight maintenance was controlled at the 12th month. Results: Although weight loss among participants varied, the mean body weights were significantly decreased by 8.2% in full-attenders (n = 30). A significant increase in HDL-cholesterol and decreases in heart rate and blood pressure were found. SF-36 summary scales were significantly improved. Weight change was moderately correlated with exercise duration, compliance to diet, and baseline mental component score. It was determined that 62.5% of the participants either lost or maintained body weight at the 12th month. Conclusion: Significant weight loss and quality of life improvement was achieved in this pilot study.GVs may be a promising alternative to primary care consultations for obesity management; however, the high dropout level and diverse outcomes need further assessment.

Aim: Today, one in every five people in our country is obese. In women, obesity and overweight are more common than men. It's an important concept that needs to be investigated to find out the reasons why some people can not adopt a healthy lifestyle and can not say ''no'' to food which can be reached easily and is promoted with provocative advertisements, or the reasons for rapid recovery of weight lost after treatment, and also to determine the relationship between all of them and impulsiveness. We aimed to determine the level of impulsivity in normal, overweight, obese women in this study. Material and Methods:The study is cross-sectional and the data are collected on a voluntary basis. The study was conducted with 200 female participants. Barratt Impulsiveness Scale (Bis-11) scale and demographic information form was applied to the sampled women. Normal, overweight and obese groups was determined impulsivity and compared Results: There was no statistically significant difference between the demographic data of the participants (p>0.05). A statistically significant difference was found in the total score of overweight and obesegroup(62.20±4.29, 61.44±4.64, 64.65±6.37) (p<0.05). There was statistically significant difference between groups in non-planning subscale scores(23.88±2.39, 23.70±2.15, 25.07±3.12)(p<0.05). Conclusion:In our study, impulsivity scores were found higher in the obese group compatible with the studies in the literature. Measuring the levels of impulsivity of individuals may be useful in obesity, which is one of the most important problems in reducing the non-communicable disease burden, and rapidly increasing in the current consumption world.