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Novel Schiff base ligand based on coumarin precursor was prepared by the condensation of 3-acetyl coumarin with 3-aminophenol. The newly synthesized Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) complexes were characterized by elemental analysis, molar conductivity, spectroscopic techniques (IR, 1 H NMR, mass spectrometry, UV-Vis), and thermal analysis (TG/DTG) to predict their structures. The resulting data displays octahedral complexes with 1M:1L ratio. The IR confirmed that the ligand coordinated to the metal ions in tridentate mode with ONO coordination sites. The complexes decomposed with three to five steps within the temperature range 30-900 C. Additionally, mass spectra of the ligand and its Cu(II) complex offer well matching data with calculated value. The molar conductivity values pointed out that the complexes were non-electrolytes. Molecular optimization of prepared compositions at DFT/ LANL2DZ level, besides Molecular docking between Schiff base ligand (HL) and the receptors of breast cancer were executed. Additionally, antibacterial activity has been evaluated against Streptococcus aureus and Escherichia coli. Additionally, fungicidal activity was screened in vitro against Aspergillus flavus and Candida albicans, using the disc diffusion method. The [Co(HL)Cl2.H2O].4H2O complex exhibits the highest antimicrobial effect against Streptococcus aureus with inhibition area 17mm, while against Escherichia coli it records 14mm, and 12mm against Candida albicans. The [Mn(L)Cl2.H2O].4H2O complex shows the lowest IC50 against human cancer (MCF-7 cells viability) with 22.2 µg/ml.

Background Stroke can affect any portion of the central nervous system leading to a wide variety of symptoms depending on the part that is involved. Diffusion tensor imaging (DTI) is an emerging neuroimaging technique that allows measuring the integrity of white matter tracts. Objectives The objective of this study is to find out if the diffusion tensor tractography technique can provide prognostic information regarding clinical outcome following ischemic stroke. Subjects and methods Forty patients with acute ischemic stroke were studied with DTI. Size of infraction, degree of reduction of fractional anisotropy (FA), and pattern of corticospinal tract (CST) affection were identified. We assessed our patients according to the National Institute of Health Stroke Scale (NIHSS) and Medical Research Council (MRC) scale at onset of stroke and 3 months later. Results FA reduction was correlated with MRC and NIHSS on admission (P < 0.001, 0.004 respectively) and after 3 months (P < 0.001, 0.013 respectively). The pattern of CST affection was associated with NIHSS and MRC after 3 months (P = 0.035, 0.001 respectively). Conclusion DTI may be an indirect indicator of the ischemic stroke outcome.