Cilia, the plural form of the cilium, are located in nearly all eukaryotic cells, from single-cell organisms to humans. The ability to respond to repellents, regulate cell proliferation and differentiation, and provide cellular mobility are just a few examples of how crucial cilia are to cells and organisms. Numerous distinct rare disorders generally known as ciliopathy are caused by abnormalities or functional impairments in the cilia and cilia-related compartments. There are an increasing number of ciliopathies and ciliopathy genes, but no up-to-date database exists that contains all disease names, genes related to those diseases, clinical symptoms, and potential disease candidate genes. Here we present CiliaMiner, a manually curated ciliopathy database that includes ciliopathy lists collected from articles and web sources. CiliaMiner offers easy access to disease names, disease genes, and clinical features, specificity to clinical features based on gene or subcellular localization of each protein. Additionally, the orthologs of disease genes are also provided for mice, zebrafish, Xenopus, Drosophila, and C. elegans. For a straightforward display of clinical characteristics and disease genes, CiliaMiner has extensive, highly enriched interactive heatmaps, aims to serve the cilia community, and will be regularly updated.
Cilia are found in eukaryotic species ranging from single-celled organisms, such as Chlamydomonas reinhardtii, to humans, but not in plants. The ability to respond to repellents and/or attractants, regulate cell proliferation and differentiation and provide cellular mobility are just a few examples of how crucial cilia are to cells and organisms. Over 30 distinct rare disorders generally known as ciliopathy are caused by abnormalities or functional impairments in cilia and cilia-related compartments. Because of the complexity of ciliopathies and the rising number of ciliopathies and ciliopathy genes, a ciliopathy-oriented and up-to-date database is required. Here, we present CiliaMiner, a manually curated ciliopathy database that includes ciliopathy lists collected from articles and databases. Analysis reveals that there are 55 distinct disorders likely related to ciliopathy, with over 4000 clinical manifestations. Based on comparative symptom analysis and subcellular localization data, diseases are classified as primary, secondary or atypical ciliopathies. CiliaMiner provides easy access to all of these diseases and disease genes, as well as clinical features and gene-specific clinical features, as well as subcellular localization of each protein. Additionally, the orthologs of disease genes are also provided for mice, zebrafish, Xenopus, Drosophila, Caenorhabditis elegans and Chlamydomonas reinhardtii. CiliaMiner (https://kaplanlab.shinyapps.io/ciliaminer) aims to serve the cilia community with its comprehensive content and highly enriched interactive heatmaps, and will be continually updated.
Database URL: https://kaplanlab.shinyapps.io/ciliaminer/
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