There are various neurologic manifestations of Multiple Myeloma (MM) seen either at presentation or as a complication of various anti-myeloma agents administered during the course of the disease. These neurologic complications might occasionally be challenging to diagnose and treat. Peripheral nervous system is more commonly affected and peripheral neuropathy is the most common form of neurologic complications seen in MM. Here we report a gentleman with MM on regular renal replacement therapy developed severe myoclonus 3 days status post autologous stem cell (ASCT). Besides MM, he had Hypertension and Diabetes Mellitus as to his renal failure. He was also suffering from neuropathy for which gabapentin was commenced.