The Mediterranean basin has significant natural resources including a proven diversity of flora. The Anacardiaceae family has around 800 tropical and subtropical species, with some representatives around the Mediterranean. Most of the plants of this family are non- toxic plant. They even have many properties. Our work consists to study the bio-insecticidal power of essential oils of Pistacia lentiscus and Pistacia atlantica of the Anacardiaceae family in the Tlemcen region by molecular modeling methods to inhibition of the enzyme α-amylase which is a digestive enzyme of Dociostaurus maroccanus using phenolics compounds derived from essentiels oil of aromatic plants: Elemol; Spathulenol; Myrcene; Beta- myrcene; Terpinen-4-ol; Bornyl acetate. Elemol give the best docking score, its interactions with α-amylase has the lowest energy score compared to the other complexes.