No abstract

We aimed to investigate the efficacy of L-type voltage gated calcium channel blocker nitrendipine and levetiracetam in pentylenetetrazole (PTZ) kindled male rats. In order to establish kindling model, 35 mg/kg PTZ injected intraperitoneally (i.p.) to male wistar albino rats three days a week. Then, screw electrodes were placed in the skulls of the kindled rats. During the experiments, EEG activities and seizure behaviors of kindled rats were recorded. The kindled rats were divided into control (n=6), PTZ (n=6), nitrendipine (2.5 mg/kg (n=6), 5 mg/kg (n=6), 10 mg/kg (n=6)) and levetiracetam (10 mg/kg (n=6), 20 mg/ kg (n=6), 40 mg/kg (n=6)) groups. Nitrendipine (5 mg/kg) and levetiracetam (20 mg/kg) were suppressed the spike frequency and the seizure score effectively (p<0.05). The effective doses of nitrendipine (5 mg/kg) and levetiracetam (20 mg/kg) were administered consecutively to the kindled animals (n=6). The co-administration of nitrendipine (5 mg/kg) and levetiracetam (20 mg/kg) did not effectively decrease the spike frequency and seizure score (p>0.05). The co-administration of nitrendipine and levetiracetam was not more effective than administration of nitrendipine or levetiracetam separately (p>0.05).