7%). Of the 177 isolates, 173 (97.7%) were resistant to at least 1 antimicrobial, while 164 (92.7%) were resistant to ≥2 antimicrobials. Resistance of isolated organisms was 76.3% to amoxicillin, 71.2% to penicillin, 56.9% to vancomycin, 39.5% to ceftriaxone and norfloxacin and 31.1% to gentamicin. The susceptibility of S. aureus was 64.4% to gentamicin but it was 100% resistant to amoxicillin. All isolates of P. aeruginosa were resistant to penicillin and amoxicillin. The rate of resistance of S. aureus to 2 or more antimicrobials was 97.8% and that of P. aeruginosa was 100%. This study confirms that the bacteria commonly implicated in post-operative wound infections: S. aureus, Klebsiella, E. coli, CoNS, and P. aeruginosa, continued to dominate and have developed high level of drug resistance to some important antibiotics. Periodic surveillance of the species of bacteria involved in post-operative wound infection and determination of their antimicrobial resistance is recommended for empirical treatment.