Selective inhibition sintering (SIS) is a powder based that fabricate functional parts through fusion of powder bed on a layer by layer basis. Being a new fabrication method, the correlation between process variables and part properties are not fully comprehended. Polyamide 12 (nylon 12) is one of the widely used materials in powder based AM processes including SIS. Therefore, in this work, the effect of critical SIS process parameters on the fatigue behavior of polyamide 12 parts was experimentally investigated, and the parameter settings were optimized to maximize fatigue strength. The number of experimental runs was determined based on Box-Behnken design, and specimens were fabricated as per ASTM D7791. Specimens were tested by subjected them to fluctuating loading at a frequency of 3 Hz. The test results were analyzed using Minitab statistical analysis software. From the ANOVA result, it was identified that the fatigue life of SIS parts is significantly influenced by layer thickness, heater temperature, and heater feed rate. Optimization of process variables settings was performed using the Minitab response optimizer and maximum fatigue strength of 17.43 MPa was obtained. The verification experiment resulted in 17.93 MPa fatigue strength which is comparable to the predicted value and with the result from the literatures.

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