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Conditioning regimens used during stem cell transplant provide prolonged control or cure of the disease in patients with acute lymphoblastic leukemia (ALL). In this study, we present a comparison of treatment results for 95 patients with ALL who underwent allogeneic hematopoietic stem cell transplant (AHSCT) with total body irradiation plus cyclophosphamide (TBI + Cy) or busulfan plus cyclophosphamide (Bu + Cy) as conditioning regimen. Median age was 25 (range: 9-54) years. Median follow-up was 24 (range: 3-107) months. Median overall survival (OS) was found to be 29 months. Median event-free survival (EFS) was 9 months. Median OS was 37 months in the TBI + Cy arm, while it was 12 months in the Bu + Cy arm, suggesting a significant advantage favoring the TBI + Cy arm (p = 0.003). Median EFS was 13 months in the TBI + Cy arm, while it was 4 months in the Bu + Cy arm, indicating a significant difference (p = 0.006). In univariate and multivariate analysis, it was found that high OS and EFS were significantly correlated with TBI + Cy conditioning regimen and lack of transplant-related mortality (p < 0.05). The TBI + Cy conditioning regimen was found to be superior to the Bu + Cy regimen in patients with ALL undergoing AHSCT regarding both OS and EFS.

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No significant differences could be found in analgesic or pain scores and bone scintigraphy results between the groups. Our results suggest that reduced-dose radiotherapy produces similar response rates and response durations when used concomitantly with zoledronic acid.

Background MRI and PET/CT scans are the main supportive methods for nasopharyngeal cancer (NPC) for staging and planning. The aim of this study is to compare MRI and PET/CT scanning in terms of survival in patients with NPC who had MRI or PET/CT‐simulated radiotherapy planning. Methods Pathological diagnosed nonkeratinized undifferentiated type and stage II‐IVA 91 NPC patients with treated intensity‐modulated radiotherapy plus chemotherapy were scanned. The patients were immobilized by a customized thermoplastic mask for fusion images both MRI scans and PET/CT scans. CTVs were created via MR‐guided simulation and PET/CT‐guided simulation. Results PET/CT‐guided simulation was performed with 44 patients (56.4%) and MR‐guided simulation was performed with 34 patients (43.6%). Local recurrence‐free survival (LRFS) of patients was 68.1 months. LRFS of patients with PET/CT‐guided simulation was 59.9, while LRFS of patients with MR‐guided was 66.9 months. There was a statistically significant difference between groups (P = .03). In the subgroup analyses, the patients were assessed by dividing into the three groups for the T1‐T2 stage, T‐3 stage, and T‐4 stage. In the patients with T1‐T2 stage, 5‐year LRFS rates were found %74.4 for PET/CT‐guided simulation and %83.3 for MR‐guided simulation. There was no statistically significant difference between groups (P = .33). In the patients with T‐3 stage, 5‐year LRFS rates were found %55.6 for PET/CT‐guided simulation and %83.3 for MR‐guided simulation. There was not a statistically significant difference between groups (P = .59). In the patients with T‐4 stage, 5‐year LRFS rates were found %42.2 for PET/CT‐guided simulation and %85.1 for MR‐guided simulation. The difference between groups was found to be statistically significant (P = .04). Conclusion In this study, we founded that MR‐guided simulation has better than PET/CT‐guided simulation for LRFS.