This study aimed to determine the effect of capital structure, firm size, firm growth on firm value with profitability as an intervening variable in LQ45 companies listed on the Indonesia Stock Exchange in 2018-2020. The sample used is 33 LQ45 companies during the period 2018-2020. This research uses multiple linear regression and path analysis. The results showed that the capital structure had a significant adverse effect on profitability and firm value. Meanwhile, firm size and growth do not significantly affect profitability and firm value. Profitability has a significant positive effect on firm value. Indirectly, capital structure affects firm value through profitability, while firm size and growth do not indirectly affect firm value.