Wallace region is mostly comprised of the southeast archipelagoes of Indonesia, namely West and East Nusa Tenggara. Lombok is a west border of the Wallace line which biologically delineate the distinguished fauna and climate in the eastern Indonesia. However, the pristine natural resource is under climatic and anthropogenic threat. A case study by means of a Descriptive method was conducted to identify any contradictive use of natural resource leading to environmental degradation, as well as to study ruination impact of climate uncertainty. Long term satellite images of Lombok from 1980’s up to the latest date were traced to identify any changes in land cover, land use and settlement. Climate data were analyzed to find its trend and forecast its potential impact on the environment. Overall, the results showed that the pristine environments, namely forests, hillocks and cliffs, particularly in tourism destination sites had been accordingly overburdened by contradictive use of resources. Lack of law enforcements in environmental protection was a key point to be addressed as a major factor resulted in losses of the most valuable value of Lombok natural scene. In addition, manmade disaster is becoming more frequent with climate change commonly accused. In conclusion, the future of the natural resource in Lombok would not be merely relied on world class facilities of tourism industry, but on to what extend effort to naturally sustain the beauty of natural scene, stop degrading the lands and be responsible to protect environment in line with regional development.