Over recent years, chemically-induced hibernation has attracted much attention in fields of hibernation biology, medical science and space biology.1,2 Several compounds such as thyronamine and gaseous H 2 S are shown to trigger hibernation-like state (HS) in non-hibernator mice.3,4 For instance, a single-dose administration of thyronamine elicited rapid suppression of metabolic rate, body temperature (T b ) and heart rate, and elevated utilization of lipid over carbohydrate for metabolism in the laboratory mice.3,5 From the perspective of HS induction, 3-iodothyronamine (T 1 AM) has drawn a particular attention because it is an endogenous compound derived from deiodination and decarboxylation of thyroid hormone T 4 (thyroxine). The compound is shown to cause little side effect or damage on neural and other critical organs even for a long-term, repeated administration.3,6a,7 These findings render T 1 AM to have pharmaceutical benefits that can be applied to emergency medical care (e.g., stroke, hypoxic assault), organ transplantation, and a long-duration spaceflight.

No abstract

The introduced synthesis has the advantages of reduced synthetic steps and significantly enhanced overall yield compared to the conventional method.