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A new method for the determination of tinidazole based on the fluorescence quenching of citrate-capped Mn-modified CdSe/CdS quantum dots was developed. In aqueous solution, the fluorescence of the quantum dots at 610 nm was quenched gradually with the increase of the concentration of tinidazole. Based on this, a simple, fast, low-cost and specific quantitative method for tinidazole detection was set up. Under optimal conditions, a good linearity was built between the fluorescence quenching of Mn-modified CdSe/CdS quantum dots and the concentration of tinidazole in the range of 4-400 microM with a correlation coefficient of 0.9998. The limit of detection (3sigma/K) was 0.4 microM. The proposed method was applied to the detections of tinidazole in tablets and injections with satisfactory results.

This work describes a new nanosensor for one-step ultrasensitive naked-eye detection of creatinine based on the target-triggered aggregation of silver nanoparticles showing dramatically enhanced Tyndall effect.

A new equipment-free colorimetric nanosensor was initially developed for quantitative point-of-need detection of nanomolar Hg2+ ions based on the enhancement in Tyndall effect of Au nanoparticles via their target-triggered “double” aggregation.