In a pooled analysis of data from 5 statin trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy.

Major depression is common in patients hospitalized with CHF and is independently associated with a poor prognosis.

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ONG-TERM THERAPY WITH STATIN drugs has been shown to reduce the risk for death, myocardial infarction (MI), and stroke among patients with established coronary artery disease, even when low-density lipoprotein (LDL) cholesterol levels are not elevated. 1-4 Most of the landmark clinical trials evaluating statins for secondary prevention enrolled patients who were stable for at least several months after an index acute coronary syndrome (ACS) event. 1-3 More recently, 2 ran-domized controlled trials have evaluated earlier initiation of statin therapy following an ACS event and have noted a corresponding early reduction in major cardiovascular events. 5,6

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