Trabecular BMD and trabecular bone microstructure in particular are severely altered in patients with clinical OI-I and OI-III-IV. Low TBS and DXL and their significant associations to HR-pQCT parameters of trabecular bone support this conclusion.

Breast cancer patients younger than 50 years with technically resectable hepatic metastases, minimal extrahepatic tumour and positive HER2 expression appear to be suitable candidates for liver resection with curative intent. An aggressive multi-disciplinary management of those patients including surgical treatment may improve long-term survival.

A system, particularly a decision-making concept, that facilitates highly automated driving on freeways in real traffic is presented. The system is capable of conducting fully automated lane change (LC) maneuvers with no need for driver approval. Due to the application in real traffic, a robust functionality and the general safety of all traffic participants are among the main requirements. Regarding these requirements, the consideration of measurement uncertainties demonstrates a major challenge. For this reason, a fully integrated probabilistic concept is developed. By means of this approach, uncertainties are regarded in the entire process of determining driving maneuvers. While this also includes perception tasks, this contribution puts a focus on the driving strategy and the decision-making process for the execution of driving maneuvers. With this approach, the BMW Group Research and Technology managed to drive 100% automated in real traffic on the freeway A9 from Munich to Ingolstadt, showing a robust, comfortable, and safe driving behavior, even during multiple automated LC maneuvers.Index Terms-Advanced driver-assistance systems (ADASs), highly automated driving, lateral vehicle guidance, probabilistic decision making.

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