Background:In the currently published literature, a higher risk for developing
arthrofibrosis after anterior cruciate ligament (ACL) reconstruction has
been reported for female patients, adolescents, early surgery or concomitant
procedures, and the use of a patellar tendon autograft. There is a lack of
evidence regarding other graft choices or factors.Hypothesis:Multiple risk factors will play a significant role in the development of
arthrofibrosis after ACL reconstruction. Specifically, we hypothesized that
the risk of manipulation under anesthesia (MUA) and/or lysis of adhesions
(LOA) would be affected by graft choice and patient demographic factors.Study Design:Case-control study; Level of evidence, 3.Methods:The charts of all patients who underwent ACL reconstruction over a 10-year
period at a single academic institution were queried from an electronic
medical record database and reviewed at a minimum of 6 months after ACL
reconstruction, with the collection of demographic and surgical data. The
relative risk for undergoing MUA and/or LOA was calculated for each analyzed
risk factor.Results:A total of 2424 ACL reconstructions were included, with a chart review at a
mean of 56.7 months after surgery (range, 7.6-124.0 months). The rate of MUA
and/or LOA for arthrofibrosis was 4.5%. A statistically significantly
increased relative risk was found for infection (5.45), hematoma requiring
evacuation (3.55), ACL reconstruction with meniscal repair (2.83), use of a
quadriceps tendon autograft (2.68), age <18 years (2.39), multiple
concomitant procedures (1.69), contact injury (1.62), female sex (1.60), and
surgery within 28 days of injury (1.53), and a statistically significantly
decreased relative risk was found for revision ACL reconstruction (0.30),
age >25 years (0.34), and use of a tibialis anterior allograft (0.36). In
the multivariate regression model, the use of a quadriceps tendon autograft
(P = .00007), infection (P = .00126),
and concomitant meniscal repair (P = .00194) were
independent risk factors, whereas revision ACL reconstruction
(P = .0024) was an independent protective factor.Conclusion:Graft type, infection, concomitant meniscal repair, and primary
reconstruction are significant risk factors for undergoing MUA or LOA after
ACL reconstruction.