The Boston Residential Investigation on Green and Healthy Transitions (BRIGHT) Study is focused on quantifying the effects of redeveloping public housing developments into new buildings with improved energy performance and indoor environmental quality. This report presents an analysis of utility consumption and work order requests at Old Colony and Washington-Beech, two redeveloped housing sites in Boston, Massachusetts. We compare the consumption of electricity, natural gas, and water, as well as work order data, from 2012–2014 to development-wide baseline data from 2006–2009. We found that despite the higher number of electric appliances in the new apartments (e.g., air conditioning and ranges), electricity consumption decreased 46% in Old Colony and nearly 30% in Washington-Beech when compared to the baseline data. Natural gas used for space heating decreased by more than 70% at both sites; and water use decreased by nearly 56% at Old Colony and nearly 30% at Washington-Beech. Work order categories that directly influence the residents’ quality of life, such as pests, mold, windows and plumbing decreased by more than 50% in both renovated sites. In combination with previous documentation of health improvements in the redeveloped sites, these results provide further evidence of the magnitude of benefits from updating public housing infrastructure using green design principles.

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The impact of plasmapheresis on the disposition of disopyramide was investigated in a 16-year-old female with systemic lupus erythematosus. Determination of total disopyramide plasma concentrations immediately prior to and following a 4-h plasmapheresis treatment revealed a significant reduction (i.e., 1.77 to 0.7 mg/l or approximately 60%). However, reassessment of the total serum concentration after 1.5 h (i.e., post equilibrium) revealed a rebounding of the value to 1.64 mg/l. Associated with this reduction in total serum levels was a decrease in the protein-bound fraction of disopyramide from 69.5% (pre treatment) to 48.6% (post treatment) that corresponded to a commensurate reduction in the concentration of alpha1-acid glycoprotein (i.e., 119 mg/dl pre treatment to 48.9 mg/dl post treatment). Despite these alterations in disopyramide concentrations, the procedure removed only 2.7% of the disopyramide dose and was not associated with the appearance of a cardiac dysrhythmia.