By their young adult years, ADHD youth were at high risk for a wide range of adverse psychiatric outcomes including markedly elevated rates of antisocial, addictive, mood and anxiety disorders. These prospective findings provide further evidence for the high morbidity associated with ADHD across the life-cycle and stress the importance of early recognition of this disorder for prevention and intervention strategies.

The association between executive function deficits (EFDs) and functional outcomes were examined among children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Participants were children and adolescents with (n = 259) and without (n = 222) ADHD, as ascertained from pediatric and psychiatric clinics. The authors defined EFD as at least 2 executive function measures impaired. Significantly more children and adolescents with ADHD had EFDs than did control participants. ADHD with EFDs was associated with an increased risk for grade retention and a decrease in academic achievement relative to (a) ADHD alone, (b) controlled socioeconomic status, (c) learning disabilities, and (d) IQ. No differences were noted in social functioning or psychiatric comorbidity. Children and adolescents with ADHD and EFDs were found to be at high risk for significant impairments in academic functioning. These results support screening children with ADHD for EFDs to prevent academic failure.

ncbi.nlm.nih.gov OBJECTIVE Despite growing interest in adult attention-deficit/hyperactivity disorder (ADHD), little is known about prevalence or correlates. METHODS A screen for adult ADHD was included in a probability sub-sample (n= 3199) of 18-44 year old respondents in the ... Geciteerd door 914-Verwante artikelen-Alle 19 versies [PDF] The IMAGE project: methodological issues for the molecular genetic analysis of ADHD [PDF] van biomedcentral.comJ Kuntsi, BM Neale, W Chen, SV Faraone…-Behav Brain …, 2006biomedcentral.com Abstract The genetic mechanisms involved in attention deficit hyperactivity disorder (ADHD) are being studied with considerable success by several centres worldwide. These studies confirm prior hypotheses about the role of genetic variation within genes involved in the ... Geciteerd door 71-Verwante artikelen-HTML-versie-Alle 17 versies Genetics of adult attention-deficit/hyperactivity disorder.

Lower birth weight due to fetal growth restriction is associated with higher blood pressure later in life, but the extent to which preterm birth (<37 completed weeks’ gestation) or very low birth weight (<1500g) predicts higher blood pressure is less clear. We performed a systematic review of 27 observational studies that compared the resting or ambulatory systolic blood pressure, or diagnosis of hypertension, among children, adolescents, and adults born preterm or very low birth weight with those born full term. We performed a meta-analysis with the subset of 10 studies that reported the resting systolic blood pressure difference in mmHg with 95% confidence intervals or standard errors. We assessed methodological quality with a modified Newcastle-Ottawa scale. The 10 studies comprised 1342 preterm or very low birth weight and 1738 full term participants from 8 countries. The mean gestational age at birth of the preterm participants was 30.2 weeks (range, 28.8 to 34.1), birth weight 1280 grams (1098 to 1958), and age at systolic blood pressure measurement 17.8 years (6.3 to 22.4). Former preterm or very low birth weight infants had higher systolic blood pressure than full term infants (pooled estimate 2.5 mmHg, 95% CI: 1.7, 3.3). For the 5 highest quality studies, the systolic blood pressure difference was slightly greater, 3.8 mmHg (95% CI 2.6, 5.0). We conclude that infants who are born preterm or very low birth weight have modestly higher systolic blood pressure later in life, and may be at increased risk for developing hypertension and its sequelae.