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Bisphosphonate medications are widely prescribed for the treatment of osteoporosis and cancer metastases to bone. However, these medications are among a list of agents which are implicated in medication related osteonecrosis of the jaw (MRONJ). A variety of non-surgical and surgical approaches are indicated in the treatment of this condition, depending on disease severity. This case series demonstrates the success of the mylohyoid flap in combination with platelet rich fibrin (PRF) in achieving closure of necrotic bony defects.

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