Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. Moreover, on-demand products are currently missing from the PrEP development portfolio. Griffithsin (GRFT) is a non-antiretroviral HIV entry inhibitor derived from red algae with an excellent safety profile and potent activity in vitro. When combined with carrageenan (CG), GRFT has strong activity against herpes simplex virus-2 (HSV-2) and human papillomavirus (HPV) in vitro and in vivo. Here, we report that GRFT/CG in a freeze-dried fast dissolving insert (FDI) formulation for on-demand use protects rhesus macaques from a high dose vaginal SHIV SF162P3 challenge 4 h after FDI insertion. Furthermore, the GRFT/CG FDI also protects mice vaginally against HSV-2 and HPV pseudovirus. As a safe, potent, broad-spectrum, on-demand non-antiretroviral product, the GRFT/CG FDI warrants clinical development.

In this study, we tested for a set of complex, nonlinear relationships between derailing/ dark side personality composites and leadership performance using two independent samples of managers/leaders (N ¼ 1306 and N ¼ 290 for Study 1 and 2, respectively). Based on the structure and characteristics of the derailing/dark side trait composites, we expected the relationship between these composites and leadership performance would best be described with an inverted U function. In Study 1, we found evidence of a nonlinear relationship between the derailing composite, as measured by the Global Personality Inventory & , and behaviorally based, structured ratings of leadership performance in an assessment center. Similarly, Study 2 found evidence for a nonlinear relationship between dark side composites, as measured by the Hogan Development Survey & , and supervisory/other ratings of leadership performance. We discuss the implications of these complex, nonlinear findings with respect to the continued use of personality for the selection and promotion of future leaders. Limitations of the current study and directions for future research are noted.

The aim of this study was to define objectively gait function in children with treated congenital talipes equinovarus (CTEV) and a good clinical result. The study also attempted an analysis of movement within the foot during gait. We compared 20 children with treated CTEV with 15 control subjects. Clinical assessment demonstrated good results from treatment. Three-dimensional gait analysis provided kinematic and kinetic data describing movement and moments at the joints of the lower limb during gait. A new method was used to study movement within the foot during gait. The data on gait showed significantly increased internal rotation of the foot during walking which was partially compensated for by external rotation at the hip. A mild foot drop and reduced plantar flexor power were also observed. Dorsiflexion at the midfoot was significantly increased, which probably compensated for reduced mobility at the hindfoot. Patients treated for CTEV with a good clinical result should be expected to have nearly normal gait and dynamic foot movement, but there may be residual intoeing, mild foot drop, loss of plantar flexor power with compensatory increased midfoot dorsiflexion and external hip rotation.

Experimental measurements using a laser Doppler anemometer (LDA) system have been performed on 150μm dense glass particles in a fully developed downward channel flow in air. Tests were conducted in smooth, rough development, and fully rough wall conditions with a channel Reynolds number of 13,800, corresponding to a centerline gas phase velocity of 10.5m∕s with a dilute loading of particles of 15% by mass fraction. Velocities were measured and statistics compared to see the nature of the effects of the wall roughness in a rebuilt channel facility originally used for important works including Kulick, Fessler, and Eaton, (1994, “Particle Response and Turbulence Modification in Fully-Developed Channel flow,” J. Fluid Mech., 277, pp. 109–134) and Paris (2001, “Turbulence Attenuation in a Particle-Laden Channel Flow,” Ph.D. thesis, Stanford University, Stanford, CA). Wall roughness has a substantial impact on gas phase mean velocities across most of the channel width, except very near the wall. The turbulence intensity of the gas phase is enhanced across the entire channel in the presence of fully rough walls. The rough walls have an even greater impact on the particle phase. Streamwise particle velocities are reduced up to 40%, and become quite uniform across the channel. Particle fluctuating velocities are nearly doubled near the channel centerplane. Profiles appear uniform, due in large part to strong transverse mixing induced by particle-wall collisions. Much of the data of Kulick and Paris is shown here to be strongly influenced by wall conditions with poorly defined roughness in the development region, followed by rapid flow recovery in a relatively smooth test section.

Purpose High-resolution visualization of cartilage canals has been restricted to histological methods and contrast-enhanced imaging. In this study, the feasibility of non-contrast-enhanced susceptibility weighted imaging (SWI) for visualization of the cartilage canals was investigated ex vivo at 9.4 T, further explored at 7 and 3 T and demonstrated in vivo at 7 T, using a porcine animal model. Methods SWI scans of specimens of distal femur and humerus from 1 to 8 week-old piglets were conducted at 9.4 T using 3D-GRE sequence and SWI post-processing. The stifle joints of a 2-week old piglet were scanned ex vivo at 7 and 3 T. Finally, the same sites of a 3-week-old piglet were scanned, in vivo, at 7 T under general anesthesia using the vendor-provided sequences. Results High-contrast visualization of the cartilage canals was obtained ex vivo, especially at higher field strengths; the results were confirmed histologically. In vivo feasibility was demonstrated at 7 T and comparison of ex vivo scans at 3 and 7 T indicated feasibility of using SWI at 3 T. Conclusions High-resolution 3D visualization of cartilage canals was demonstrated using SWI. This demonstration of fully noninvasive visualization opens new avenues to explore skeletal maturation and the role of vascular supply for diseases such as osteochondrosis.