Ampullary tumors are relatively rare, but the occurrence of biliary obstruction early in the disease course facilitates diagnosis. With technologic advances, methods of diagnosis, treatment, and management of ampullary tumors are constantly evolving. However, despite rapid improvements in these areas, preoperative differentiation between adenomas and adenocarcinomas remains difficult. Forcep biopsy specimens can accurately detect the presence or absence of adenomatous changes, but they have a high false-negative rate for adenocarcinoma. Whereas it is generally agreed that all ampullary tumors should be removed or resected, patient selection for the various treatments, including pancreatoduodenectomy, local resection, and endoscopic treatment, remains controversial. Stage of disease, patient characteristics (ie, age and comorbid conditions), and local availability of expertise determine treatment options.

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The definition of Barrett's esophagus is conceptually simple. It is the replacement of the normal squamous mucosa by specialized intestinal metaplasia within the esophagus. Barrett's esophagus would only be a clinical curiosity if not for its predisposition toward neoplastic change. In spite of all the knowledge and data gathered thus far on Barrett's, much remains unknown. Why do some patients develop Barrett's while others do not? Why do some with Barrett's advance to adenocarcinoma? Once Barrett's develops, what is the optimal prevention strategy for adenocarcinoma? These clinical unknowns touch only the tip of the iceberg and have made Barrett's esophagus a subject of intense research. This review offers some of the highlights from Digestive Disease Week 2003, comprised of posters of distinction and oral presentations.