No abstract

Purpose: Machine learning algorithms are best trained with large quantities of accurately annotated samples. While natural scene images can often be labeled relatively cheaply and at large scale, obtaining accurate annotations for medical images is both time consuming and expensive. In this study, we propose a cooperative labeling method that allows us to make use of weakly annotated medical imaging data for the training of a machine learning algorithm. As most clinically produced data are weakly-annotated -produced for use by humans rather than machines and lacking information machine learning depends uponthis approach allows us to incorporate a wider range of clinical data and thereby increase the training set size. Methods: Our pseudo-labeling method consists of multiple stages. In the first stage, a previously established network is trained using a limited number of samples with high-quality expert-produced annotations. This network is used to generate annotations for a separate larger dataset that contains only weakly annotated scans. In the second stage, by cross-checking the two types of annotations against each other, we obtain higher-fidelity annotations. In the third stage, we extract training data from the weakly annotated scans, and combine it with the fully annotated data, producing a larger training dataset. We use this larger dataset to develop a computer-aided detection (CADe) system for nodule detection in chest CT. Results: We evaluated the proposed approach by presenting the network with different numbers of expert-annotated scans in training and then testing the CADe using an independent expert-annotated dataset. We demonstrate that when availability of expert annotations is severely limited, the inclusion of weakly-labeled data leads to a 5% improvement in the competitive performance metric (CPM), defined as the average of sensitivities at different false-positive rates. Conclusions: Our proposed approach can effectively merge a weaklyannotated dataset with a small, well-annotated dataset for algorithm training. This approach can help enlarge limited training data by leveraging the large amount of weakly labeled data typically generated in clinical image interpretation.

We introduce Evenly Cascaded convolutional Network (ECN), a neural network taking inspiration from the cascade algorithm of wavelet analysis. ECN employs two feature streams -a low-level and high-level steam. At each layer these streams interact, such that low-level features are modulated using advanced perspectives from the high-level stream. ECN is evenly structured through resizing feature map dimensions by a consistent ratio, which removes the burden of ad-hoc specification of feature map dimensions. ECN produces easily interpretable features maps, a result whose intuition can be understood in the context of scale-space theory. We demonstrate that ECN's design facilitates the training process through providing easily trainable shortcuts. We report new state-of-the-art results for small networks, without the need for additional treatment such as pruning or compression -a consequence of ECN's simple structure and direct training. A 6-layered ECN design with under 500k parameters achieves 95.24% and 78.99% accuracy on CIFAR-10 and CIFAR-100 datasets, respectively, outperforming the current state-of-the-art on small parameter networks, and a 3 million parameter ECN produces results competitive to the state-of-the-art.