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A model system, utilizing shear-sensitive protozoa, has been developed for characterizing the disruptive forces in agitated systems. The model system gives a measure of the maximum shear stresses in the apparatus being tested, and is particularly useful when tissue fragility is a factor in fernientor design. The time dependency of protozoan disruption is shown and discussed. Breakdown data in conventional stirred vessels and a laminar shear device are presented and discussed.

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