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The OBMT regimen used in this study is safe and effective against metronidazole-sensitive H pylori strains.

Calcium release-activated calcium channels (CRAC) play unambiguous role in secretory functions of mast cells, T cells, and eosinophils. Less knowledge exists about the role of CRAC, widely distributed in airway smooth muscle (ASM) cells, in airway contractility. The presented study seeks to determine the possible participation of CRAC in ASM-based inflammatory airway disorders in guinea pigs. The acute and long-term administration (14 days) of the CRAC antagonist 3-fluoropyridine-4-carboxylic acid was used to examine the ASM contractility and associated reflexes in the guinea pig model of allergic airway inflammation by the following methods: (i) evaluation of specific airway resistance in vivo; (ii) evaluation of the contractile response of isolated ASM strips in vitro; and (iii) citric acid-induced cough reflex; (iv) measurement of exhaled NO levels (E(NO)). Allergic airway inflammation was induced by repetitive exposure of guinea pigs to ovalbumin (10(-6) M). The CRAC antagonist administered in a single dose to guinea pigs with confirmed allergic inflammation significantly reduced the cough response and the airway resistance, which corresponded with the findings in vitro. Long-term application of the CRAC antagonist had more strongly expressed effects. The results confirm the role of CRAC in the pathophysiology of experimental animal asthma and have a potential meaning for anti-asthma therapy.

Objectives Relate the primary reasons palliative care consultations are ordered in an academic medical center. Propose strategies for expanding palliative care in underserved areas. Original Research Background. The University of Alabama at Birmingham (UAB) launched one of the first comprehensive PC programs in the U.S. in an area of the country with the lowest PC access. Research Objectives. To examine UAB PC program trends from 2004-2015 to plan for future Southeast expansion. Methods. Retrospective electronic-record review of inpatient consultation, palliative care comfort unit (PCCU), and outpatient clinic trends.

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