On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ∼ 1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40 − 8 + 8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 M ⊙ . An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ∼ 40 Mpc ) less than 11 hours after the merger by the One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ∼10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ∼ 9 and ∼ 16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta.

ForewordThe Pierre Auger Observatory has begun a major Upgrade of its already impressive capabilities, with an emphasis on improved mass composition determination using the surface detectors of the Observatory. Known as AugerPrime, the upgrade will include new 4 m 2 plastic scintillator detectors on top of all 1660 water-Cherenkov detectors, updated and more flexible surface detector electronics, a large array of buried muon detectors, and an extended duty cycle for operations of the fluorescence detectors.This Preliminary Design Report was produced by the Collaboration in April 2015 as an internal document and information for funding agencies. It outlines the scientific and technical case for AugerPrime 1 . We now release it to the public via the arXiv server. We invite you to review the large number of fundamental results already achieved by the Observatory and our plans for the future.The Pierre Auger Collaboration 1 As a result of continuing R&D, slight changes have been implemented in the baseline design since this Report was written. These changes will be documented in a forthcoming Technical Design Report. ix x Executive Summary Present Results from the Pierre Auger ObservatoryMeasurements of the Auger Observatory have dramatically advanced our understanding of ultra-high energy cosmic rays. The suppression of the flux around 5×10 19 eV is now confirmed without any doubt. Strong limits have been placed on the photon and neutrino components of the flux indicating that "top-down" source processes, such as the decay of superheavy particles, cannot account for a significant part of the observed particle flux. A largescale dipole anisotropy of ∼7% amplitude has been found for energies above 8×10 18 eV. In addition there is also an indication of the presence of a large scale anisotropy below the ankle. Particularly exciting is the observed behavior of the depth of shower maximum with energy, which changes in an unexpected, non-trivial way. Around 3×10 18 eV it shows a distinct change of slope with energy, and the shower-to-shower variance decreases. Interpreted with the leading LHC-tuned shower models, this implies a gradual shift to a heavier composition. A number of fundamentally different astrophysical model scenarios have been developed to describe this evolution. The high degree of isotropy observed in numerous tests of the small-scale angular distribution of UHECR above 4×10 19 eV is remarkable, challenging original expectations that assumed only a few cosmic ray sources with a light composition at the highest energies. Interestingly, the largest departures from isotropy are observed for cosmic rays with E > 5.8×10 19 eV in ∼20 • sky-windows. Due to a duty cycle of ∼15% of the fluorescence telescopes, the data on the depth of shower maximum extend only up to the flux suppression region, i.e. 4×10 19 eV. Obtaining more information on the composition of cosmic rays at higher energies will provide crucial means to discriminate between the model classes and to understand the origin of the observed flux suppre...

The budding yeast, Saccharomyces cerevisiae, was grown exponentially at different rates in the presence of growth rate-limiting concentrations of a protein synthesis inhibitor, cycloheximide. The volumes of the parent cell and the bud were determined as were the intervals of the cell cycle devoted to the unbudded and budded periods. We found that S. cerevisiae cells divide unequally. The daughter cell (the cell produced at division by the bud of the previous cycle) is smaller and has a longer subsequent cell cycle than the parent cell which produced it. During the budded period most of the volume increase occurs in the bud and very little in the parent cell, while during the unbudded period both the daughter and the parent cell increase significantly in volume. The length of the budded interval of the cell cycle varies little as a function of population doubling time; the unbudded interval of the parent cell varies moderately; and the unbudded interval for the daughter cell varies greatly (in the latter case an increase of 100 min in population doubling time results in an increase of 124 rain in the daughter cell's unbudded interval). All of the increase in the unbudded period occurs in that interval of G1 that precedes the point of cell cycle arrest by the S. cerevisiae amating factor. These results are qualitatively consistent with and support the model for the coordination of growth and division (Johnston, G. C., J. R. Pringle, and L. H. Hartwell. 1977. Exp. Cell. Res. 105:79-98.) This model states that growth and not the events of the DNA division cycle are rate limiting for cellular proliferation and that the attainment of a critical cell size is a necessary prerequisite for the "start" event in the DNA-division cycle, the event that requires the cdc 28 gene product, is inhibited by mating factor and results in duplication of the spindle pole body.KEY WORDS Saccharornyces cerevisiae yeast 9 division kinetics 9 unequal division G1 control growth controlObservations made with organisms as diverse as bacteria, fungi, and animal cells suggest that the attainment of a critical cell mass is a necessary prerequisite for the initiation of the cell cycle, an event that is usually evidenced by the onset of DNA replication. In 1968 Donachie (7) noted that the observations of Schaechter et al. (27), demonstrating a proportionality between the log of the individual cell mass and the growth rate for Salmonella typhimurium taken together with the Cooper and Helmstetter (6) model for the timing of DNA replication in Escherichia coli, revealed that the initiation of chromosome replication took 422

In this paper we review air shower data related to the mass composition of cosmic rays above 10 15 eV. After explaining the basic relations between air shower observables and the primary mass and energy of cosmic rays, we present different approaches and results of composition studies with surface detectors. Furthermore, we discuss measurements of the longitudinal development of air showers from non-imaging Cherenkov detectors and fluorescence telescopes.The interpretation of these experimental results in terms of primary mass is highly susceptible to the theoretical uncertainties of hadronic interactions in air showers. We nevertheless attempt to calculate the logarithmic mass from the data using different hadronic interaction models and to study its energy dependence from 10 15 eV to 10 20 eV.

he Pierre Auger Observatory, located on a vast, high plain in western\ud Argentina, is the world's largest cosmic ray observatory. The objectives\ud of the Observatory are to probe the origin and characteristics of cosmic\ud rays above 10(17) eV and to study the interactions of these, the most\ud energetic particles observed in nature. The Auger design features an\ud array of 1660 water Cherenkov particle detector stations spread over\ud 3000 km(2) overlooked by 24 air fluorescence telescopes. In addition,\ud three high elevation fluorescence telescopes overlook a 23.5 km(2),\ud 61-detector infilled array with 750 in spacing. The Observatory has been\ud in successful operation since completion in 2008 and has recorded data\ud from an exposure exceeding 40,000 km(2) sr yr. This paper describes the\ud design and performance of the detectors, related subsystems and\ud infrastructure that make up the Observatory