2D materials are at the forefront of materials research, advancing in applications for biomedical and bio/sensing. We elucidate properties of 2D materials beyond graphene that are relevant to those applications, as well as their correlation with toxicity.
Mechanisms of cisplatin antineoplastic action are beyond DNA binding. Alternative effects of cisplatin that can support a good therapeutic response are discussed in this review.
During the past few years, growing attention has been paid to black phosphorus (BP) and its unique optical, electrical, and catalytic properties. Furthermore, BP has proven to be biocompatible and biodegradable; qualities that present new opportunities for its utilization in the field of life sciences. However, despite all its suitable properties and applicability, its utilization in biomedicine is still in its infancy. This study reports on the synthesis of black phosphorus nanoparticles (BP NPs) and exploration of thier applicability in targeted drug delivery. BP NPs are loaded with platinum agents—cisplatin and oxaliplatin—and subjected to in vitro evaluation of targeted drug delivery. The BP NPs are not only able to load the investigated platinum derivatives on their surfaces, but also to transfer the therapeutic cargo to target specific tissue and to combine their effect with oxaliplatin, which leads to further potentiation of the anticancer effect.
The prospective intensive utilization of two-dimensional (2D) nanomaterials, such as graphene, transition metal dichalcogenides, and black phosphorus, increased the requirements for thorough comprehension of their potential impact on the environment and health.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.