Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections worldwide. HPV infection has a strong relationship with the onset of cervix uteri, vagina, penis, anus, and oropharynx, but also tonsils and tongue cancers. Some epidemiological data indicate that except for gynecologic cancers, HPV infection can be one of the risk factors associated with a greater risk of induction and progression of gastrointestinal cancers. Data, however, remain contradictory and definite conclusions cannot be drawn, so far. The following review aims to organize recent evidence and summarize the current state of knowledge regarding the association between HPV infection and gastrointestinal tumors primarily focusing on esophageal, liver, gastric, colorectal, and anal cancers.

Introduction and purpose: Isotretinoin, the vitamin A derivative, has been commonly used in treatment of acne vulgaris for years. Despite its unquestionable efficacy, chronic oral isotretinoin treatment leads to multiple side effects. The aim of study is analysis of musculoskeletal symptoms prevalence during oral isotretinoin treatment and their impact on physical activity.Material and methods: The study was conducted using the original survey questionnaire shared online among members of Polish group of patients treated for acne. Total of 196 responses were analyzed and compared with up-to-date literature related to the topic.Results: 86,7% of respondents reported at least one of the musculoskeletal symptoms. The most common were back pain (82,7%), fatigue and lethargy (70,4%), myalgia (55,1%) and arthalgia (32,1%). In 97,6% cases adverse effects were developed within the first 6 months of treatment. In 64,2% they persisted during the whole therapy, sometimes even beyond. Due to musculoskeletal side effects, in 2,4% cases dose reduction was necessary, 1,8% of respondents had to stop treatment and 48% had to limit or stop physical activity. 71,4% of repondents reported that lower back pain occurred or escalated during isotretinoin treatment.Conclusions: Prevalence of reported musculoskeletal symptoms is very high and totals 86,7%. They result in prolonged limiting or stopping of physical activity in almost 50% of people. Although musculoskeletal symptoms are typically benign, possibility of severe disorders and potential permanent effects must be taken into consideration.

Study on the state of knowledge of medical students about the glycemic index of popular food products in Poland. A survey study.

Introduction: Hericium erinaceus is a medicinal and culinary mushroom that is widely present in the countries of East Asia. Bioactive compounds derived from the fruiting body or its mycelium have many properties, including: antioxidant, antidiabetic, anti-inflammatory, as well as hypolipidemic properties. It also has the potential to treat neurological disorders as it contains neurotrophic compounds that can cross the blood-brain barrier. Aim of the study: The aim of this work is to review scientific research on the potential properties of the H. erinaceus in treating diseases of the nervous system. Results: Many studies have shown that Hericium erinaceus can bring the desired effects as a complementary treatment and be an alternative in the treatment of depressive and cognitive disorders and, due to its strong neuroprotective nature, be used in Alzheimer's disease or in post-traumatic brain injury. Most of the cited studies concern experiments carried out on animal models. Conclusion: Due to the evidence of potentially neuroprotective properties of H. erinaceus, there is a need for further clinical trials in humans.

Proper nutrition is an important element in pursuit of health. Appropriate selection of macroand micro-ingredients allows to maintain the correct weight, avoid nutritional deficiencies and many health problems. Despite the fact that the topic of nutrition is primarily the concern of nutritionists, knowledge of nutrition is often helpful also for doctors. Aim is to examine the state of knowledge of medical students studying in Poland on the principles of healthy eating. Material and Methods: An anonymous online survey was conducted. The responses of 140 students of medicine from Polish medical universities were analyzed. Results: Despite the fact that 52.1% of the respondents declared that they are interested in the topic of healthy eating, only 40.3% of the respondents correctly stated that buckwheat is a good source of magnesium in the diet. 72.7% of respondents wrongly thought that olive oil is a good source of omega-3 fatty acids in the diet. 78.1% of respondents correctly stated that canned food with a high salt content is a risk factor for stomach cancer. 52.5% of respondents believe that coffee increases the excretion of magnesium in the urine. The same number of respondents correctly considered green tea to be a source of substances similar to caffeine. 59.7% of respondents correctly stated that onions, leeks and cabbage should be avoided while following the diet recommended in irritable bowel syndrome. Conclusion: Despite the expressed interest in the subject of healthy eating by the majority of the surveyed students, the results of the study suggest that the dietetary knowledge of students of the medical faculty of Polish Medical Universities is not very good. In some questions, only about half of the respondents gave correct answers.