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We examined the immunofluorescence and ultrastructural changes of insulin-producing B cells in the center and at the periphery of islets of Langerhans during in vivo stimulation by glucose and glibenclamide. A decreased insulin immunostaining was detected in islets from the splenic rat pancreas after 1. IntroductionStudies on the insulin-producing B cells of the islets of Langerhans are usually performed with the implicit assumption that these cells are all alike and secrete synchronously and homogeneously under most conditions. There is, however, evidence that B cells may be structurally and functionally different. Thus, within an islet, neighboring B cells show variable amounts of secretory granules and rough endoplasmic reticulum (1) and different thresholds for glucose-induced electrical activity (2,3).

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